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But karma can change by pious activity, so in that way, you can do something about your destiny and you can improve it. But there's different types of piety. Material piety will give you material benefit, but piety related to Krsna, that is another thing.
That is the kind of piety that can change your life!
(Kadamba Kanana Swami, Durban, 04/04/2010)